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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HMGCR
All Species:
46.67
Human Site:
Y514
Identified Species:
73.33
UniProt:
P04035
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P04035
NP_000850.1
888
97476
Y514
S
S
L
Q
Y
L
P
Y
R
D
Y
N
Y
S
L
Chimpanzee
Pan troglodytes
XP_001148324
888
97313
Y514
S
S
L
Q
Y
L
P
Y
R
D
Y
N
Y
S
L
Rhesus Macaque
Macaca mulatta
XP_001104607
888
97210
Y514
S
S
L
Q
Y
L
P
Y
R
D
Y
N
Y
S
L
Dog
Lupus familis
XP_536323
888
97475
Y514
S
S
L
Q
Y
L
P
Y
R
D
Y
N
Y
S
L
Cat
Felis silvestris
Mouse
Mus musculus
Q01237
887
97003
Y513
S
S
L
Q
Y
L
P
Y
R
D
Y
N
Y
S
L
Rat
Rattus norvegicus
P51639
887
96670
Y513
S
S
L
Q
Y
L
P
Y
R
D
Y
N
Y
S
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_989816
875
95421
Y501
S
S
L
Q
Y
L
P
Y
R
N
Y
N
Y
S
L
Frog
Xenopus laevis
P20715
883
96702
Y509
S
A
L
Q
S
L
P
Y
K
N
Y
N
Y
S
L
Zebra Danio
Brachydanio rerio
NP_001119931
893
97691
Y519
S
T
L
S
C
L
P
Y
K
D
Y
D
Y
S
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P14773
920
98299
Y541
G
R
L
D
V
L
P
Y
E
H
F
D
Y
R
K
Honey Bee
Apis mellifera
XP_623118
908
99432
Y512
D
Y
L
S
N
L
P
Y
K
D
Y
D
Y
S
K
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
P16393
932
100947
Y530
D
A
L
E
K
L
P
Y
A
S
Y
D
Y
S
F
Poplar Tree
Populus trichocarpa
Maize
Zea mays
O24594
579
60912
Y240
L
L
D
G
R
R
F
Y
L
P
M
A
T
T
E
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P14891
592
63579
D253
I
A
G
P
L
L
L
D
G
Y
E
Y
S
V
P
Baker's Yeast
Sacchar. cerevisiae
P12683
1054
115607
Y669
L
A
S
D
R
L
P
Y
K
N
Y
D
Y
D
R
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
98.7
95.7
N.A.
93.3
92.7
N.A.
N.A.
85.1
80.9
77.8
N.A.
47.2
51.2
N.A.
56.3
Protein Similarity:
100
99.7
99.3
97.3
N.A.
96
95.8
N.A.
N.A.
91.6
89.5
86.7
N.A.
64.6
69.2
N.A.
70.6
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
93.3
73.3
60
N.A.
33.3
53.3
N.A.
46.6
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
100
93.3
80
N.A.
46.6
66.6
N.A.
66.6
Percent
Protein Identity:
N.A.
33.5
N.A.
34.5
35.1
N.A.
Protein Similarity:
N.A.
46.8
N.A.
47.5
51
N.A.
P-Site Identity:
N.A.
6.6
N.A.
6.6
33.3
N.A.
P-Site Similarity:
N.A.
13.3
N.A.
13.3
60
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
27
0
0
0
0
0
0
7
0
0
7
0
0
0
% A
% Cys:
0
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
14
0
7
14
0
0
0
7
0
54
0
34
0
7
0
% D
% Glu:
0
0
0
7
0
0
0
0
7
0
7
0
0
0
7
% E
% Phe:
0
0
0
0
0
0
7
0
0
0
7
0
0
0
7
% F
% Gly:
7
0
7
7
0
0
0
0
7
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
7
0
0
0
0
0
% H
% Ile:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
7
0
0
0
27
0
0
0
0
0
20
% K
% Leu:
14
7
80
0
7
94
7
0
7
0
0
0
0
0
54
% L
% Met:
0
0
0
0
0
0
0
0
0
0
7
0
0
0
0
% M
% Asn:
0
0
0
0
7
0
0
0
0
20
0
54
0
0
0
% N
% Pro:
0
0
0
7
0
0
87
0
0
7
0
0
0
0
7
% P
% Gln:
0
0
0
54
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
7
0
0
14
7
0
0
47
0
0
0
0
7
7
% R
% Ser:
60
47
7
14
7
0
0
0
0
7
0
0
7
74
0
% S
% Thr:
0
7
0
0
0
0
0
0
0
0
0
0
7
7
0
% T
% Val:
0
0
0
0
7
0
0
0
0
0
0
0
0
7
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
7
0
0
47
0
0
94
0
7
80
7
87
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _